SCHEMBL9784698

SCHEMBL9784698

COc1cc(C[S+]([O-])c2nc3cc4c(cc3[nH]2)OCO4)ncc1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 7/20 0.38
ATP4A P20648 4/20 0.38
ATP4B P51164 4/20 0.38
BRS3 P32247 5/20 0.35
ATP1A1 P05023 2/20 0.35
ATP1B1 P05026 2/20 0.35
ATP1A3 P13637 2/20 0.35
ATP1B2 P14415 2/20 0.35
ATP1A2 P50993 2/20 0.35
ATP1B3 P54709 2/20 0.35
FXYD2 P54710 2/20 0.35
ATP1A4 Q13733 2/20 0.35
ALDH1A1 P00352 2/20 0.32
RAB9A P51151 1/20 0.32
FGFR1 P11362 1/20 0.31
FGFR2 P21802 1/20 0.31
MEN1 O00255 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6883039 0.92 ATP4A (0.45) PDE10AATP4AATP4BBRS3ALDH1A1
SCHEMBL10368630 0.87 ATP4A (0.43) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL10368552 0.86 ATP4A (0.53) PDE10AATP4AATP4BATP1A1ATP1B1
SCHEMBL10375022 0.86 ATP4A (0.46) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL6459040 0.85 ATP4A (0.45) PDE10AATP4AATP4BBRS3ALDH1A1
SCHEMBL6881048 0.83 PDE10A (0.35) PDE10AATP4AATP4BBRS3ATP1A1
SCHEMBL10843919 0.82 PDE10A (0.42) PDE10ABRS3ALDH1A1RAB9AMEN1
SCHEMBL10934661 0.82 ATP4A (0.43) ATP4AATP4BATP1A1ATP1B1ATP1A3
SCHEMBL9793531 0.82 BRS3 (0.41) PDE10AATP4AATP4BBRS3ATP1A1
SCHEMBL6881365 0.81 ATP4A (0.47) PDE10AATP4AATP4BBRS3ATP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4981861-A ANTIULCER HOFFMANN-LA ROCHE INC. (US) 1991-01-01 US disclosed
US-4634710-A ANTIULCER, ANTISECRETORY HOFFMANN-LA ROCHE INC. (US) 1987-01-06 US disclosed
EP-0163842-A1 Tricyclic imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1985-12-11 EP disclosed