Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.46 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.46 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.46 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.46 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.40 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.39 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.39 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.39 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9786053 | 0.91 | SLC2A1 (0.43) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL9786103 | 0.90 | SLC2A1 (0.47) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL7280733 | 0.90 | ADRB2 (0.56) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL9786002 | 0.89 | SLC2A1 (0.43) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL9786042 | 0.89 | SLC2A1 (0.43) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL9786063 | 0.89 | SLC2A1 (0.43) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9786076 | 0.89 | SLC2A1 (0.44) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7280271 | 0.88 | ADRB2 (0.57) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7286608 | 0.88 | ADRB2 (0.49) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL7271915 | 0.85 | ADRB2 (0.56) | SLC2A1ADORA3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023378-A | Hypotensive agents, antiischemic agents, urogenital disorders | GLAXO GROUP LIMITED (GB) | 1991-06-11 | — | — | US | disclosed |
| EP-0188361-B1 | AMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-03-06 | — | — | EP | disclosed |
| EP-0188361-A1 | Amine derivatives | GLAXO GROUP LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |