Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786663 | 0.77 | KDM4E (0.32) | KDM4ERXFP1 | |
| SCHEMBL276284 | 0.68 | CYP1A2 (0.56) | BRD4KDM4ESMN1; SMN2GAAKMT2A | |
| SCHEMBL7037055 | 0.65 | — | — | |
| SCHEMBL9787252 | 0.63 | PDE4A (0.45) | KDM4ESMN1; SMN2MAPT | |
| SCHEMBL24263869 | 0.62 | BRD4 (0.67) | BRD4CREBBPBRPF1EP300PDK2 | |
| SCHEMBL16543118 | 0.61 | BRD4 (0.50) | BRD4CREBBPBRPF1EP300PDK2 | |
| SCHEMBL20577753 | 0.61 | CYP2C19 (0.44) | BRPF1KDM4ESMN1; SMN2GAAMAPT | |
| SCHEMBL21916084 | 0.61 | BRD4 (0.55) | BRD4CREBBPBRPF1EP300PDK2 | |
| SCHEMBL15436509 | 0.60 | PTPN11 (0.43) | BRD4CREBBPBRPF1EP300PDK2 | |
| SCHEMBL21547813 | 0.60 | BRD4 (0.36) | BRD4CREBBPBRPF1EP300PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5002961-A | Antiischemic Agents, Preventing Reperfusion Injuries | MERRELL DOW PHARMACEUTICALS (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0078546-B1 | NOVEL IMIDAZOLECARBOXAMIDE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-11-12 | — | — | EP | disclosed |
| EP-0078546-A1 | Novel imidazolecarboxamide derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-05-11 | — | — | EP | disclosed |