Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | THPO | P40225 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11129281 | 1.00 | TSHR (0.39) | TSHRPMP22THRBBLMNPSR1 | |
| SCHEMBL9786618 | 1.00 | TSHR (0.39) | TSHRPMP22THRBBLMNPSR1 | |
| SCHEMBL3069874 | 0.76 | — | — | |
| SCHEMBL11604305 | 0.76 | TSHR (0.53) | TSHRPMP22THRBBLMNPSR1 | |
| SCHEMBL11604316 | 0.76 | TSHR (0.53) | TSHRPMP22THRBBLMNPSR1 | |
| SCHEMBL11604297 | 0.76 | TSHR (0.53) | TSHRPMP22THRBBLMNPSR1 | |
| SCHEMBL10663631 | 0.73 | THRB (0.31) | TSHRPMP22THRBBLMNPSR1 | |
| SCHEMBL10663626 | 0.73 | THRB (0.31) | TSHRPMP22THRBBLMNPSR1 | |
| SCHEMBL9786626 | 0.73 | — | — | |
| SCHEMBL9786621 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5002961-A | Antiischemic Agents, Preventing Reperfusion Injuries | MERRELL DOW PHARMACEUTICALS (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0312960-A2 | Method for reducing reperfusion injury with imidazol-2-thione-carboxamides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-04-26 | — | — | EP | disclosed |
| EP-0078546-B1 | NOVEL IMIDAZOLECARBOXAMIDE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-11-12 | — | — | EP | disclosed |
| EP-0064705-B1 | 5-AMINOMETHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| EP-0064706-B1 | 5-(4-PHENYL-1-PIPERIDINYL)METHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| US-4391759-A | Process for the preparation of organothioaldoxime compounds | UNION CARBIDE CORPORATION (US) | 1983-07-05 | — | — | US | disclosed |
| EP-0078546-A1 | Novel imidazolecarboxamide derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-05-11 | — | — | EP | disclosed |
| US-4371737-A | CARDIOTONICS, ANTIHYPERTENSIUES AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-02-01 | — | — | US | disclosed |
| EP-0064706-A1 | 5-(4-Phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| EP-0064705-A1 | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329470-A | CORDIOTONIC, HYPOTENSIVE, ANTITHROMBOSIS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4161591-A | SUBSTITUTED 2-(CARBAMOYL)OXYIMINO-3-IMINO-BUTYRAMIDES AND -BUTYRATES, APHIDICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-07-17 | — | — | US | disclosed |
| US-4151296-A | APHIDICIDES, SYSTEMIC AND FOLIAR | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-04-24 | — | — | US | disclosed |
| US-4059623-A | APHIDICIDE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-11-22 | — | — | US | disclosed |