Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551186 | 0.88 | LMNA (0.59) | LMNARECQLALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL9564637 | 0.83 | LMNA (0.68) | LMNARECQLALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL28112525 | 0.83 | CYP4F2 (0.43) | LMNAALDH1A1KDM4ETSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL8899736 | 0.81 | APP (0.48) | LMNAALDH1A1L3MBTL1ADRB2ADRB1 | |
| SCHEMBL8901490 | 0.81 | CYP2C9 (0.44) | LMNAALDH1A1L3MBTL1MAPTTSHR | |
| SCHEMBL29752747 | 0.79 | TSHR (0.61) | ALDH1A1L3MBTL1ADRB3KDM4EMAPT | |
| SCHEMBL668899 | 0.79 | KMT2A (0.48) | LMNAALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL15861779 | 0.78 | CYP1A2 (0.51) | LMNACYP2D6L3MBTL1KDM4EMAPT | |
| SCHEMBL6395059 | 0.78 | LMNA (0.52) | LMNARECQLALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL10476983 | 0.78 | LMNA (0.52) | LMNARECQLALDH1A1CYP2D6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2236137-B1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF FATTY LIVER DISEASES | ASTELLAS PHARMA INC (JP) | 2015-06-24 | — | — | EP | disclosed |
| US-20110003757-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING FATTY LIVER DISEASE | ASTELLAS PHARMA INC. (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-2236137-A1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF FATTY LIVER DISEASES | Astellas Pharma Inc. (JP) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003757-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING FATTY LIVER DISEASE | SLC5A1, SLC5A2, SLC10A1 | LMNA 3041/4885RECQL 4708/4885ALDH1A1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.