Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.39 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6151962 | 0.82 | TAAR1 (0.48) | AOC3TAAR1SLC6A2SIGMAR1CYP2A6 | |
| Bromide SCHEMBL11038152 | 0.74 | TAAR1 (0.58) | AOC3TAAR1SLC6A2CYP2A6MAOA | |
| SCHEMBL22750940 | 0.73 | TAAR1 (0.47) | AOC3TAAR1SLC6A2SIGMAR1CYP2A6 | |
| SCHEMBL21058275 | 0.72 | TAAR1 (0.45) | AOC3TAAR1SLC6A2CYP2A6MAOA | |
| SCHEMBL21058237 | 0.71 | TAAR1 (0.54) | AOC3TAAR1SLC6A2CYP2A6MAOA | |
| SCHEMBL5003745 | 0.71 | TAAR1 (0.48) | AOC3TAAR1SLC6A2CYP2A6MAOA | |
| SCHEMBL451516 | 0.71 | TAAR1 (0.60) | AOC3TAAR1SLC6A2CYP2A6MAOA | |
| Hydrochloric Acid SCHEMBL11164072 | 0.70 | TAAR1 (0.58) | AOC3TAAR1SLC6A2CYP2A6MAOA | |
| Water SCHEMBL2959270 | 0.70 | TAAR1 (0.58) | AOC3TAAR1SLC6A2CYP2A6MAOA | |
| Bromide SCHEMBL499589 | 0.69 | SMN1; SMN2 (0.41) | AOC3TAAR1SLC6A2SIGMAR1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992549-A | Herbicidal compositions | CIBA-GEIGY CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |