Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.89 |
| ▸ | RORC | P51449 | 5/20 | 0.89 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.89 |
| ▸ | USP2 | O75604 | 1/20 | 0.89 |
| ▸ | LMNA | P02545 | 1/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.89 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.89 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.76 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.76 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.75 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.73 |
| ▸ | CRYAB | P02511 | 1/20 | 0.73 |
| ▸ | HMGCR | P04035 | 1/20 | 0.73 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.73 |
| ▸ | ITGAV | P06756 | 1/20 | 0.73 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.73 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.71 |
| ▸ | DHCR24 | Q15392 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL10481854 | 0.94 | OSBP (0.96) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21650234 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21707472 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL22225160 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL23579652 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL23365796 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL22095727 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL23761109 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21340667 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21447271 | 0.94 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093100-A1 | ORGANIC NITRATES AS IGNITION ENHANCERS | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 2013-06-27 | — | — | WO | disclosed |
| US-20130160354-A1 | ORGANIC NITRATES AS IGNITION ENHANCERS | SHELL OIL COMPANY (US) | 2013-06-27 | — | — | US | disclosed |
| US-5049389-A | Non-phospholipd lipid, delivery by inhalation | LIPOSOME TECHNOLOGY, INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-5043165-A | Cholesterol and salt; antiallergens, antiinflammatory agents, skin disorders | LIPOSOME TECHNOLOGY, INC. (US) | 1991-08-27 | — | — | US | disclosed |
| US-4906476-A | Novel liposome composition for sustained release of steroidal drugs in lungs | LIPOSOME TECHNOLOGY, INC. | 1990-03-06 | — | — | US | disclosed |
| US-4035060-A | Electro-optic device | DAINIPPON PRINTING CO., LTD (JA) | 1977-07-12 | — | — | US | disclosed |
| US-3944330-A | Electro-optic device | DAINIPPON PRINTING CO., LTD. (JA) | 1976-03-16 | — | — | US | disclosed |