Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 11/20 | 0.63 |
| ▸ | ATP4B | P51164 | 11/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974700 | 0.81 | ROCK1 (0.47) | ATP4AATP4BROCK1ROCK2ALDH1A1 | |
| SCHEMBL9789001 | 0.81 | ATP4A (0.61) | ATP4AATP4BROCK1ROCK2RAB9A | |
| SCHEMBL9789065 | 0.80 | ATP4A (0.63) | ATP4AATP4BROCK1ROCK2ALDH1A1 | |
| SCHEMBL9789069 | 0.80 | ATP4A (0.65) | ATP4AATP4BROCK1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL10454848 | 0.80 | ROCK1 (0.46) | ATP4AATP4BROCK1ROCK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9788958 | 0.80 | ATP4A (0.66) | ATP4AATP4BROCK1ALDH1A1KDM4E | |
| SCHEMBL3807660 | 0.78 | ATP4A (0.61) | ATP4AATP4BMAPT | |
| SCHEMBL9789104 | 0.75 | ATP4A (0.67) | ATP4AATP4BROCK1ALDH1A1KDM4E | |
| SCHEMBL9789101 | 0.75 | ATP4A (0.69) | ATP4AATP4BROCK1ALDH1A1MAPT | |
| SCHEMBL9792754 | 0.74 | ATP4A (0.64) | ATP4AATP4BROCK1ROCK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259085-B1 | 2-GUANIDINO-4-ARYLTHIAZOLES FOR TREATMENT OF PEPTIC ULCERS | PFIZER INC. (US) | 1991-08-21 | — | — | EP | disclosed |
| US-5026715-A | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0259085-A1 | 2-Guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1988-03-09 | — | — | EP | disclosed |