SCHEMBL9790296

SCHEMBL9790296

Oc1c(Cc2ccccc2)cc(Cl)cc1Cc1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.67
HIF1A Q16665 2/20 0.67
CYP3A4 P08684 2/20 0.67
HPGD P15428 2/20 0.67
MEN1 O00255 1/20 0.67
ALOX15 P16050 1/20 0.67
KMT2A Q03164 1/20 0.67
BCL2 P10415 1/20 0.57
BCL2L1 Q07817 1/20 0.57
CYP2C9 P11712 2/20 0.55
CYP2C19 P33261 2/20 0.55
PTPN1 P18031 3/20 0.51
PTPN2 P17706 1/20 0.51
PTPN6 P29350 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
ALDH1A1 P00352 2/20 0.50
HSP90AA1 P07900 1/20 0.50
ALOX5 P09917 1/20 0.50
LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10827098 0.91 HIF1A (0.57) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL13120855 0.87 CYP3A4 (0.57) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL8822919 0.87 CYP3A4 (0.57) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL27725677 0.87 HSD17B10 (0.57) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL9251915 0.84 HPGD (0.75) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL11882996 0.83 MEN1 (0.56) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL9804555 0.83 PTPN1 (0.70) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL9174306 0.83 PTPN1 (0.70) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL10905203 0.82 BCL2 (0.55) HSD17B10HIF1ACYP3A4HPGDMEN1
SCHEMBL11209438 0.81 PTPN1 (0.68) HSD17B10HIF1ACYP3A4HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0186255-A2 Process for preparing benzyl substituted phenols, dibenzylphenolic compounds, and the antioxidant use of such phenols ETHYL CORPORATION (US) 1986-07-02 EP claimed
US-5072017-A Condensation of para-substituted phenol with benzylating agent in presence of faujasite type zeolite; antioxidants, bactericides BAYER AKTIENGESELLSCHAFT (DE) 1991-12-10 US disclosed
EP-0278211-B1 PROCESS FOR THE MANUFACTURE OF P-SUBSTITUTED O-BENZYLPHENOLS BAYER AG (DE) 1990-08-01 EP disclosed
EP-0186255-A2 Process for preparing benzyl substituted phenols, dibenzylphenolic compounds, and the antioxidant use of such phenols ETHYL CORPORATION (US) 1986-07-02 EP disclosed