Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 12/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977107 | 0.88 | CALCRL (0.36) | CALCRLRAMP1 | |
| SCHEMBL977136 | 0.87 | CALCRL (0.38) | CALCRLHCAR3HCAR2 | |
| SCHEMBL977108 | 0.83 | CALCRL (0.31) | CALCRL | |
| SCHEMBL12921066 | 0.81 | CALCRL (0.34) | CALCRLHCAR3HCAR2RAMP1 | |
| SCHEMBL981352 | 0.80 | CALCRL (0.41) | CALCRLHCAR3HCAR2RAMP1 | |
| SCHEMBL981287 | 0.77 | CALCRL (0.38) | CALCRLHCAR3HCAR2RAMP1 | |
| SCHEMBL3583936 | 0.76 | CALCRL (0.37) | CALCRLHCAR3HCAR2RAMP1 | |
| SCHEMBL978530 | 0.76 | CALCRL (0.36) | CALCRLRAMP1 | |
| SCHEMBL977111 | 0.75 | CALCRL (0.37) | CALCRLHCAR3HCAR2RAMP1 | |
| Lithium Ion SCHEMBL977109 | 0.72 | CALCRL (0.38) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765759-B2 | Monocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2271346-B1 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-01 | — | — | EP | disclosed |
| US-20110021516-A1 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021516-A1 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | CCKAR, CALCRL, CCKBR | CALCRL 2/4885HCAR3 97/4885HCAR2 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.