Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10361626 | 0.82 | HSP90AA1 (0.49) | KMT2AMAPTHSP90AA1HDAC1HDAC8 | |
| SCHEMBL9792762 | 0.81 | CYP3A4 (0.46) | KMT2AMAPTHSP90AA1POLBCYP3A4 | |
| Nitric Acid SCHEMBL9795438 | 0.79 | KMT2A (0.34) | KMT2AMAPTHSP90AA1HDAC1HDAC8 | |
| SCHEMBL18358401 | 0.76 | KMT2A (0.62) | KMT2ASCN9AMAPTPOLBKDM4E | |
| Nitric Acid SCHEMBL9795407 | 0.75 | CYP19A1 (0.37) | KMT2ASCN9AMAPTPOLBCYP3A4 | |
| SCHEMBL9795320 | 0.74 | KMT2A (0.58) | KMT2ASCN9AMAPTPOLBKDM4E | |
| SCHEMBL9388155 | 0.73 | MAPT (0.44) | KMT2AMAPTHSP90AA1HDAC1HDAC8 | |
| Nitric Acid SCHEMBL10587061 | 0.73 | KMT2A (0.35) | KMT2ASCN9AMAPTHSP90AA1KDM4E | |
| SCHEMBL27244049 | 0.72 | KMT2A (0.64) | KMT2ASCN9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL10709771 | 0.70 | MAPT (0.43) | KMT2AMAPTHSP90AA1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032607-A | Enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-07-16 | — | — | US | disclosed |
| US-4866086-A | PHENYLTRIAZOLYL OLEFINIC AROMATASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-09-12 | — | — | US | disclosed |
| EP-0299683-A2 | Heterocyclic olefinic compounds and their use as aromatase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-01-18 | — | — | EP | disclosed |