Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL9795438 | 0.93 | KMT2A (0.34) | CYP19A1MAPTKMT2AHTTALDH1A1 | |
| SCHEMBL9795384 | 0.75 | KMT2A (0.47) | MAPTKMT2ASCN9ALMNAPOLB | |
| Nitric Acid SCHEMBL10587061 | 0.73 | KMT2A (0.35) | CYP19A1MAPTKMT2AALDH1A1RAB9A | |
| Nitric Acid SCHEMBL9795315 | 0.68 | RAB9A (0.40) | CYP19A1MAPTKMT2AHTTALDH1A1 | |
| Nitric Acid SCHEMBL9795307 | 0.68 | RAB9A (0.40) | CYP19A1MAPTKMT2AHTTALDH1A1 | |
| Nitric Acid SCHEMBL10587065 | 0.67 | FBP1 (0.37) | KMT2ALMNAMEN1 | |
| SCHEMBL10361626 | 0.61 | HSP90AA1 (0.49) | CYP19A1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL10412436 | 0.61 | TRPA1 (0.33) | CYP19A1MAPTKMT2ALMNAPOLB | |
| Nitric Acid SCHEMBL10583760 | 0.61 | MAPT (0.38) | CYP19A1MAPTKMT2AHTTALDH1A1 | |
| SCHEMBL9362865 | 0.60 | APP (0.43) | LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032607-A | Enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-07-16 | — | — | US | disclosed |
| US-4866086-A | PHENYLTRIAZOLYL OLEFINIC AROMATASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-09-12 | — | — | US | disclosed |
| EP-0299683-A2 | Heterocyclic olefinic compounds and their use as aromatase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-01-18 | — | — | EP | disclosed |