Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 2/20 | 0.30 |
| ▸ | FPR2 | P25090 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501573 | 0.94 | KDM4E (0.40) | KDM4ECYP2D6ALDH1A1TSHRSMN1; SMN2 | |
| Oxalic Acid SCHEMBL9795145 | 0.81 | KDM4E (0.38) | KDM4ECYP2D6SMN1; SMN2HSD17B10 | |
| SCHEMBL27837325 | 0.79 | KDM4E (0.41) | KDM4ECYP2D6TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL21172271 | 0.78 | KDM4E (0.45) | KDM4ECYP2D6TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL4936016 | 0.77 | KDM4E (0.48) | KDM4ECYP2D6TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL10309174 | 0.76 | SMN1; SMN2 (0.45) | KDM4ECYP2D6ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL9499958 | 0.74 | KDM4E (0.38) | KDM4ECYP2D6SMN1; SMN2HSD17B10FPR3 | |
| Oxalic Acid SCHEMBL9795510 | 0.73 | PAOX (0.42) | KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL9497821 | 0.73 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| SCHEMBL13463180 | 0.73 | KDM4E (0.43) | KDM4ECYP2D6ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |