⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796178 | 1.00 | — | — | |
| SCHEMBL15870904 | 1.00 | — | — | |
| SCHEMBL15870907 | 0.81 | MEN1 (0.45) | — | |
| SCHEMBL67849 | 0.75 | — | — | |
| SCHEMBL6158176 | 0.72 | — | — | |
| SCHEMBL14476700 | 0.72 | CCR1 (0.35) | — | |
| SCHEMBL22518503 | 0.72 | CCR1 (0.35) | — | |
| SCHEMBL18246043 | 0.72 | CCR1 (0.35) | — | |
| SCHEMBL24250845 | 0.71 | — | — | |
| SCHEMBL4449420 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788037-A1 | SUBSTITUTED PYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR | Amgen Inc. (US) | 2021-03-10 | — | — | EP | disclosed |
| EP-3541792-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | Amgen Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| EP-0224339-B1 | PYRIMIDINE DERIVATIVE, PROCESS FOR PREPARING SAME AND AGRICULTURAL OR HORTICULTURAL FUNGICIDAL COMPOSITION CONTAINING SAME | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-01-02 | — | — | EP | disclosed |