Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357662 | 0.80 | CYP19A1 (0.59) | ALDH1A1MEN1KMT2ACYP19A1 | |
| SCHEMBL9735540 | 0.78 | ALDH1A1 (0.52) | CYP3A4CYP1A2CYP2D6ALDH1A1TDP1 | |
| SCHEMBL9796198 | 0.77 | ALDH1A1 (0.62) | ALDH1A1TDP1MEN1KMT2AKDM4E | |
| SCHEMBL8208785 | 0.76 | MAPK1 (0.44) | CYP1A2CYP2D6ALDH1A1TDP1KDM4E | |
| SCHEMBL8415259 | 0.75 | GRIA2 (0.51) | CYP3A4CYP1A2ALDH1A1TDP1MEN1 | |
| SCHEMBL9796373 | 0.74 | MEN1 (0.50) | CYP3A4ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL14971513 | 0.74 | TSHR (0.45) | CYP1A2CYP2D6ALDH1A1TDP1KDM4E | |
| SCHEMBL8597802 | 0.73 | ALDH1A1 (0.47) | CYP3A4CYP2D6ALDH1A1MEN1KMT2A | |
| SCHEMBL561968 | 0.73 | NPSR1 (0.62) | CYP3A4CYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL4067424 | 0.73 | TSHR (0.60) | CYP3A4TDP1MEN1KMT2ANFKBIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990523-A | Treatment of chronic inflammatory joint disease with arylsulfonamides | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-02-05 | — | — | US | disclosed |
| WO-1990015600-A2 | TREATMENT OF CHRONIC INFLAMMATORY JOINT DISEASE WITH ARYLSULFONAMIDES | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-12-27 | — | — | WO | disclosed |