Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796452 | 0.85 | ATM (0.44) | ATMGSK3BPRKCAIDO1TDO2 | |
| SCHEMBL9796420 | 0.83 | ATM (0.43) | ATMGSK3BPRKCAIDO1TDO2 | |
| SCHEMBL9796513 | 0.75 | ALDH1A1 (0.48) | GSK3BKDM4EALDH1A1BRD4DRD2 | |
| SCHEMBL6050597 | 0.72 | ATM (0.48) | ATMIDO1TDO2KDM4EALDH1A1 | |
| SCHEMBL5441907 | 0.72 | ATM (0.44) | ATMIDO1TDO2KDM4EALDH1A1 | |
| SCHEMBL9796456 | 0.72 | ATM (0.42) | ATMGSK3BPRKCAIDO1TDO2 | |
| SCHEMBL10629394 | 0.71 | ATM (0.47) | ATMIDO1TDO2KDM4EALDH1A1 | |
| SCHEMBL9796325 | 0.70 | TP53 (0.41) | GSK3BPRKCAKDM4EALDH1A1SCN9A | |
| SCHEMBL1606274 | 0.70 | IDO1 (0.43) | ATMGSK3BPRKCAIDO1TDO2 | |
| SCHEMBL9796252 | 0.70 | ATM (0.51) | ATMGSK3BPRKCAIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |