Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 10/20 | 0.67 |
| ▸ | CA1 | P00915 | 9/20 | 0.67 |
| ▸ | CA9 | Q16790 | 9/20 | 0.67 |
| ▸ | CA12 | O43570 | 5/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639424 | 0.87 | CA1 (0.71) | POLBHTTCA2CA1CA9 | |
| SCHEMBL9463617 | 0.85 | CA1 (0.69) | CA2CA1CA9CA12ALDH1A1 | |
| SCHEMBL1972668 | 0.83 | ALDH1A1 (0.50) | POLBHTTCA2CA1CA9 | |
| SCHEMBL13556569 | 0.83 | ALDH1A1 (0.53) | POLBHTTCA2CA1CA9 | |
| SCHEMBL21102719 | 0.83 | POLB (0.63) | POLBHTTCA2CA1CA9 | |
| SCHEMBL21101932 | 0.81 | POLB (0.58) | POLBHTTCA2CA1CA9 | |
| SCHEMBL18792938 | 0.80 | CA1 (0.74) | CA2CA1CA9CA12MAPT | |
| SCHEMBL30629806 | 0.80 | CA1 (0.61) | HTTCA2CA1CA9CA12 | |
| SCHEMBL11142183 | 0.80 | CA1 (0.61) | HTTCA2CA1CA9CA12 | |
| SCHEMBL13556572 | 0.80 | MEN1 (0.72) | POLBHTTCA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990523-A | Treatment of chronic inflammatory joint disease with arylsulfonamides | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-02-05 | — | — | US | disclosed |