Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688270 | 0.83 | TP53 (0.39) | TP53CREBBPKDM4EALDH1A1HPGD | |
| SCHEMBL10378746 | 0.82 | KDM4E (0.41) | TP53CREBBPLTB4RLTB4R2KDM4E | |
| SCHEMBL7274369 | 0.80 | TP53 (0.44) | TP53CREBBPKDM4EALDH1A1HPGD | |
| SCHEMBL10379105 | 0.80 | SIGMAR1 (0.39) | TP53CREBBPALDH1A1MEN1KMT2A | |
| SCHEMBL10472794 | 0.78 | TP53 (0.40) | TP53CREBBPALDH1A1HPGDMEN1 | |
| Hydrochloric Acid SCHEMBL10379395 | 0.78 | GAA (0.40) | TP53CREBBPKDM4EALDH1A1MEN1 | |
| SCHEMBL10377920 | 0.77 | TAAR1 (0.40) | TP53CREBBPKDM4EALDH1A1HPGD | |
| SCHEMBL10377895 | 0.77 | SIGMAR1 (0.45) | — | |
| Hydrochloric Acid SCHEMBL10377705 | 0.76 | SIGMAR1 (0.44) | — | |
| SCHEMBL9688588 | 0.75 | MAPT (0.46) | TP53CREBBPMEN1KMT2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987137-A | CEREBRAL SENILITY | BEECHAM WUELFING GMBH & CO., KG (DE) | 1991-01-22 | — | — | US | disclosed |
| EP-0167901-B1 | ACTIVE COMPOUNDS | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-04-04 | — | — | EP | disclosed |
| US-4853391-A | Pyrido[1,2-a]indoles and their use as cardiovascular | LABORATOIRES SOBIO SA, 13-15-25 BOULEVARD DE 1'AMIRAL BRUIX 75782 PARIS, CEDEX 16, FRANCE | 1989-08-01 | — | — | US | disclosed |
| US-4837240-A | ANTIISCHEMIC, ANTHIHYPOXIC AGENTS | BEECHAM-WUELFING GMBH & CO. KG (FR) | 1989-06-06 | — | — | US | disclosed |
| US-4835271-A | Aminoalkyl secocanthine derivatives and their use | BEECHAM-WUELFING GMBH & CO., KG (DE) | 1989-05-30 | — | — | US | disclosed |
| EP-0252643-A1 | Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-01-13 | — | — | EP | disclosed |
| EP-0213696-A2 | Tetrahydropyrido [1,2-a] indole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Beecham Wuelfing GmbH & Co KG (DE) | 1987-03-11 | — | — | EP | disclosed |