Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9798359 | 1.00 | HRH3 (0.41) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL11084141 | 0.96 | HRH3 (0.39) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL11084144 | 0.96 | HRH3 (0.39) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL7751867 | 0.95 | GRIA1 (0.41) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL2352622 | 0.95 | GRIA1 (0.41) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL10832113 | 0.91 | ESR2 (0.40) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL9349666 | 0.91 | GRIA1 (0.39) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL10832104 | 0.91 | ESR2 (0.40) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL9511984 | 0.91 | GRIA1 (0.39) | HRH3KCNH2HRH2HRH1GRIA1 | |
| SCHEMBL9349673 | 0.91 | GRIA1 (0.39) | HRH3KCNH2HRH2HRH1GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240320-B1 | PHENYLPYRIDINE DERIVATIVES | Chisso Corporation (JP) | 1991-02-27 | — | — | EP | disclosed |
| EP-0194153-B1 | PYRIDINE DERIVATIVES | Chisso Corporation (JP) | 1990-10-31 | — | — | EP | disclosed |
| EP-0167912-B1 | LIQUID CRYSTAL MIXTURES CONTAINING COMPOUNDS WITH A 4-ALKENYL OR 2Z-ALKENYL LATERAL CHAIN | F. HOFFMANN-LA ROCHE AG (CH) | 1990-01-03 | — | — | EP | disclosed |
| US-4772416-A | LIQUID CRYSTALS | CHISSO CORPORATION (JP) | 1988-09-20 | — | — | US | disclosed |
| EP-0151294-B1 | 2-SUBSTITUTED-6-(5-SUBSTITUTED-2-PYRIMIDINYL)NAPHTHALENES AND LIQUID CRYSTAL COMPOSITIONS CONTAINING THE SAME | Chisso Corporation (JP) | 1988-06-22 | — | — | EP | disclosed |
| US-4709030-A | 4-ALKENYL OR 2Z-ALKENYL POLYPHENYL COMPOUNDS; ELECTRO-OPTICS | HOFFMANN-LA ROCHE INC. (US) | 1987-11-24 | — | — | US | disclosed |
| US-4696759-A | ESTERS, HAL, CARBO, LIQUID CRYSTALS | CHISSO CORPORATION (JP) | 1987-09-29 | — | — | US | disclosed |
| US-4684477-A | LOW VISCOSITY, LOW VOLTAGE | CHISSO CORPORATION (JP) | 1987-08-04 | — | — | US | disclosed |
| US-4668425-A | PYRIMIDINYL-PYRIDINE COMPOUNDS | CHISSO CORPORATION (JP) | 1987-05-26 | — | — | US | disclosed |
| US-4659500-A | Ester derivative having a positive dielectric anisotropy | CHISSO CORPORATION (JP) | 1987-04-21 | — | — | US | disclosed |
| EP-0202514-A2 | Liquid crystal esters | Chisso Corporation (JP) | 1986-11-26 | — | — | EP | disclosed |
| US-4621901-A | ELECTROOPTICS | HOFFMANN-LA ROCHE INC. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0194153-A2 | Pyridine derivatives | Chisso Corporation (JP) | 1986-09-10 | — | — | EP | disclosed |
| US-4585575-A | LIQUID CRYSTALS HAVING LARGE VALUE OF OPTICAL ANISOTROPY | CHISSO CORPORATION (JP) | 1986-04-29 | — | — | US | disclosed |
| US-4583826-A | Phenylethanes | HOFFMANN-LA ROCHE INC. (US) | 1986-04-22 | — | — | US | disclosed |
| EP-0151294-A1 | 2-Substituted-6-(5-substituted-2-pyrimidinyl)naphthalenes and liquid crystal compositions containing the same | Chisso Corporation (JP) | 1985-08-14 | — | — | EP | disclosed |
| US-4526704-A | Esters containing phenylene and cyclohexylene rings | HOFFMANN-LA ROCHE INC. (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0103681-A1 | Tetra- and pentacyclic monoesters | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-03-28 | — | — | EP | disclosed |