SCHEMBL9798398

SCHEMBL9798398

C=C(C)C(=O)OCCCCN(CCCCCC)c1ccc(C=Cc2ccc([N+](=O)[O-])c(C#N)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.39
ESR1 P03372 1/20 0.37
APP P05067 4/20 0.34
THRA P10827 1/20 0.34
THRB P10828 1/20 0.34
SLC16A3 O15427 1/20 0.34
SLC16A1 P53985 1/20 0.34
ATG4B Q9Y4P1 1/20 0.34
ALDH1A1 P00352 2/20 0.33
HPGD P15428 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
CACNA1F O60840 1/20 0.32
CACNA1D Q01668 1/20 0.32
CACNA1S Q13698 1/20 0.32
CACNA1C Q13936 1/20 0.32
P4HB P07237 1/20 0.32
POLB P06746 1/20 0.32
APEX1 P27695 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9798524 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9799219 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9798779 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9798337 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9798482 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9798908 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9798479 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9799273 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9798868 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2
SCHEMBL9798530 0.87 ALDH1A1 (0.39) SLC16A3SLC16A1ATG4BALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0411103-A1 NON-LINEAR OPTICAL MATERIALS WITH VICINAL DONOR OR ACCEPTOR GROUPS MERCK PATENT GmbH (DE) 1991-02-06 EP disclosed
WO-1990009616-A1 NON-LINEAR OPTICAL MATERIALS WITH VICINAL DONOR OR ACCEPTOR GROUPS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-08-23 WO disclosed