Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Triethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.85 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.31 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraethylene Glycol SCHEMBL9799385 | 1.00 | MEN1 (0.85) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL9799558 | 0.96 | — | — | |
| Triethylene Glycol SCHEMBL28966005 | 0.92 | MEN1 (0.85) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Tetraethylene Glycol SCHEMBL8733812 | 0.92 | MEN1 (0.85) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Triethylene Glycol SCHEMBL28790787 | 0.92 | MEN1 (0.85) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| Tetraethylene Glycol SCHEMBL3343601 | 0.92 | MEN1 (1.00) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL12157423 | 0.92 | MEN1 (1.00) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL12865309 | 0.92 | MEN1 (1.00) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL5145873 | 0.92 | MEN1 (1.00) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL19000749 | 0.92 | MEN1 (1.00) | MEN1KMT2ATSHRMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011739-A | Moisture stable biasable transfer members and method for making same | EASTMAN KODAK COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0421299-A2 | Moisture stable biasable transfer members and method for making same | EASTMAN KODAK COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |