Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 5/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24987391 | 0.79 | SMN1; SMN2 (0.37) | SMN1; SMN2HTR1AADRA1BADRA1A | |
| SCHEMBL24987392 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2HTR1AADRA1BADRA1A | |
| SCHEMBL24987393 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2HTR1AADRA1BADRA1A | |
| SCHEMBL24987395 | 0.76 | SMN1; SMN2 (0.33) | SMN1; SMN2HTR1AADRA1B | |
| SCHEMBL25914140 | 0.75 | SMN1; SMN2 (0.34) | SMN1; SMN2HTR1AADRA1BADRA1DADRA1A | |
| SCHEMBL9800243 | 0.75 | MAPT (0.34) | HTR1A | |
| SCHEMBL25914144 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2HTR1AADRA1BADRA1A | |
| SCHEMBL25914137 | 0.71 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL9800221 | 0.71 | HTR1A (0.32) | SMN1; SMN2HTR1AADRA1BADRA1DADRA1A | |
| SCHEMBL24987390 | 0.71 | MEN1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417143-A1 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1991-03-20 | — | — | EP | claimed |
| WO-1989011856-A2 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1989-12-14 | — | — | WO | claimed |
| EP-0417143-A1 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| WO-1989011856-A2 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1989-12-14 | — | — | WO | disclosed |