Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.76 |
| ▸ | APP | P05067 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TOP2A | P11388 | 2/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223975 | 0.92 | BACE1 (0.88) | BACE1APPMAPTHDAC2CYP2D6 | |
| SCHEMBL3223964 | 0.92 | BACE1 (0.88) | BACE1APPMAPTHDAC2CYP2D6 | |
| SCHEMBL3221705 | 0.86 | BACE1 (1.00) | BACE1HDAC2CYP2D6CYP2C9TSHR | |
| SCHEMBL3221692 | 0.86 | BACE1 (1.00) | BACE1HDAC2CYP2D6CYP2C9TSHR | |
| SCHEMBL4005087 | 0.86 | IAPP (0.71) | BACE1APPMAPTHDAC2CYP2D6 | |
| SCHEMBL4005096 | 0.86 | IAPP (0.71) | BACE1APPMAPTHDAC2CYP2D6 | |
| SCHEMBL27211513 | 0.84 | IAPP (0.73) | BACE1APPMAPTHDAC2CYP2D6 | |
| SCHEMBL3209412 | 0.83 | APP (0.84) | BACE1APPMAPTHDAC2CYP2D6 | |
| SCHEMBL3209426 | 0.83 | APP (0.84) | BACE1APPMAPTHDAC2CYP2D6 | |
| SCHEMBL22209087 | 0.82 | IAPP (0.71) | BACE1APPMAPTHDAC2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245825-B1 | STYRYL PYRAZOLES, ISOXAZOLES AND ANALOGS THEREOF HAVING ACTIVITY AS 5-LIPOXY-GENASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |