Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.67 |
| ▸ | APP | P05067 | 6/20 | 0.61 |
| ▸ | TTR | P02766 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | BACE1 | P56817 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.60 |
| ▸ | MAOA | P21397 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005096 | 1.00 | IAPP (0.71) | IAPPPTGS1APPTTRHSD17B10 | |
| Didemethylcurcumin SCHEMBL613667 | 0.91 | IAPP (0.77) | IAPPPTGS1APPTTRHSD17B10 | |
| Didemethylcurcumin SCHEMBL613666 | 0.91 | IAPP (0.77) | IAPPPTGS1APPTTRHSD17B10 | |
| SCHEMBL13810759 | 0.87 | IAPP (0.67) | IAPPPTGS1APPTTRHSD17B10 | |
| SCHEMBL9800788 | 0.86 | BACE1 (0.76) | IAPPPTGS1APPHSD17B10BACE1 | |
| SCHEMBL16881737 | 0.85 | IAPP (0.69) | IAPPPTGS1APPTTRHSD17B10 | |
| SCHEMBL29565303 | 0.85 | AKR1B1 (0.76) | IAPPAPPTTRHSD17B10BACE1 | |
| SCHEMBL3671196 | 0.85 | AKR1B1 (0.76) | IAPPAPPTTRHSD17B10BACE1 | |
| SCHEMBL3671201 | 0.85 | AKR1B1 (0.76) | IAPPAPPTTRHSD17B10BACE1 | |
| SCHEMBL14802240 | 0.84 | MMP9 (0.71) | IAPPPTGS1APPHSD17B10BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901618-B1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | SYMRISE GMBH & CO KG (DE) | 2009-06-17 | — | — | EP | claimed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | claimed |
| EP-1901618-A1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | Symrise GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | claimed |
| WO-2007003527-A1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | SYMRISE GMBH & CO. KG (DE) | 2007-01-11 | — | — | WO | claimed |
| EP-1901618-B1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | SYMRISE GMBH & CO KG (DE) | 2009-06-17 | — | — | EP | disclosed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| EP-1901618-A1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | Symrise GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007003527-A1 | HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE | SYMRISE GMBH & CO. KG (DE) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227866-A1 | Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste | TAS2R1, TAS2R5, TAS2R50 | IAPP 1523/4885PTGS1 1610/4885APP 3569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.