Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 13/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800922 | 1.00 | EPHX1 (0.63) | EPHX1ALDH1A1HTTPOLBEPHX2 | |
| SCHEMBL9800934 | 0.92 | EPHX2 (0.55) | EPHX1ALDH1A1HTTPOLBEPHX2 | |
| SCHEMBL9800932 | 0.92 | EPHX2 (0.55) | EPHX1ALDH1A1HTTPOLBEPHX2 | |
| SCHEMBL17672416 | 0.91 | EPHX1 (0.57) | EPHX1ALDH1A1HTTPOLBEPHX2 | |
| SCHEMBL9800949 | 0.89 | — | — | |
| SCHEMBL9800919 | 0.88 | EPHX1 (0.55) | EPHX1 | |
| SCHEMBL9800917 | 0.88 | EPHX1 (0.55) | EPHX1 | |
| SCHEMBL9800925 | 0.83 | EPHX1 (0.55) | EPHX1ALDH1A1HTTPOLBEPHX2 | |
| SCHEMBL9800916 | 0.83 | MAPT (0.56) | EPHX1ALDH1A1HTTPOLB | |
| SCHEMBL28341578 | 0.82 | EPHX2 (0.55) | EPHX1ALDH1A1HTTPOLBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297610-B1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | claimed |
| EP-0297610-B1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0297610-A1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1989-01-04 | — | — | EP | disclosed |