Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19426821 | 0.86 | MAPT (0.51) | MAPTALDH1A1GAAPKMHTT | |
| SCHEMBL11140712 | 0.85 | MAPT (0.45) | MAPTALDH1A1GAAPKMHTT | |
| SCHEMBL9800922 | 0.83 | EPHX1 (0.63) | ALDH1A1HTTPOLBEPHX1 | |
| SCHEMBL9800905 | 0.83 | EPHX1 (0.63) | ALDH1A1HTTPOLBEPHX1 | |
| SCHEMBL11541523 | 0.80 | ALDH1A1 (0.57) | MAPTALDH1A1GAAPKMHTT | |
| SCHEMBL11420471 | 0.80 | POLB (0.46) | MAPTALDH1A1GAAPKMHTT | |
| SCHEMBL30013382 | 0.80 | HTT (0.63) | MAPTALDH1A1GAAPKMHTT | |
| SCHEMBL9800926 | 0.79 | SOAT1 (0.66) | — | |
| SCHEMBL11417791 | 0.77 | POLB (0.48) | MAPTALDH1A1GAAPKMHTT | |
| SCHEMBL21292015 | 0.76 | LMNA (0.56) | MAPTALDH1A1GAAPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297610-B1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | claimed |
| EP-0297610-B1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0297610-A1 | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase | WARNER-LAMBERT COMPANY (US) | 1989-01-04 | — | — | EP | disclosed |