Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27699903 | 0.86 | HSD17B10 (0.54) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL10361052 | 0.85 | HSD17B10 (0.61) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL396553 | 0.84 | HSD17B10 (0.59) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL5599878 | 0.84 | HPGD (0.59) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL13121723 | 0.82 | HSD17B10 (0.58) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL8597144 | 0.82 | HSD17B10 (0.58) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL8872776 | 0.82 | HSD17B10 (0.58) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL1786599 | 0.81 | HPGD (0.53) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL12948167 | 0.81 | ALDH1A1 (0.49) | HSD17B10HPGDALOX15MAPTKDM4E | |
| SCHEMBL12948186 | 0.81 | ALDH1A1 (0.49) | HSD17B10HPGDALOX15MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11192866-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-12-07 | — | — | US | disclosed |
| EP-3138831-B1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2020-07-08 | — | — | EP | disclosed |
| EP-2016044-B1 | PENTACYCLINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS | HARVARD COLLEGE (US) | 2020-06-10 | — | — | EP | disclosed |
| US-10669244-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-11-14 | — | — | US | disclosed |
| US-9884830-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884830-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-02-06 | — | — | US | disclosed |
| EP-3138831-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | President and Fellows of Harvard College (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-3138831-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | President and Fellows of Harvard College (US) | 2017-03-08 | — | — | EP | disclosed |
| US-20160340325-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-24 | — | — | US | disclosed |
| US-20100130451-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130451-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130451-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2010-05-27 | — | — | US | disclosed |
| EP-1753713-A4 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-2016044-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | The President and Fellows of Harvard College (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007117639-A9 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007117639-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |
| EP-1753713-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | The President and Fellows of Harvard College (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050282787-A1 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-12-22 | — | — | US | disclosed |
| WO-2005112945-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11192866-B2 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | HSD17B10 2440/4885HPGD 3373/4885ALOX15 3774/4885 |
| US-20050282787-A1 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | HSD17B10 2440/4885HPGD 3373/4885ALOX15 3774/4885 |
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | HSD17B10 2440/4885HPGD 3373/4885ALOX15 3774/4885 |
| US-20100130451-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | CCNE1, CCNE2, CCNT2 | HSD17B10 3668/4885HPGD 2807/4885ALOX15 3399/4885 |
| US-10669244-B2 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | HSD17B10 2440/4885HPGD 3373/4885ALOX15 3774/4885 |
| US-20160340325-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | HSD17B10 2440/4885HPGD 3373/4885ALOX15 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.