Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.49 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.49 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.49 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | SNCA | P37840 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SHBG | P04278 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10786925 | 1.00 | HTR2A (0.54) | HTR2ASNCAKCNH2ESR1ADRA2A | |
| Bromide SCHEMBL9802080 | 1.00 | HTR2A (0.54) | HTR2ASNCAKCNH2ESR1ADRA2A | |
| Bromide SCHEMBL10623133 | 0.98 | SNCA (0.53) | HTR2ASNCAKCNH2ESR1ADRA2A | |
| Bromide SCHEMBL10455284 | 0.95 | RARB (0.51) | HTR2ASNCAKCNH2ESR1ADRA2A | |
| Bromide SCHEMBL10987732 | 0.94 | RARB (0.50) | HTR2ASNCAKCNH2ALDH1A1HSD17B10 | |
| Bromide SCHEMBL2688048 | 0.93 | SNCA (0.54) | HTR2ASNCAKCNH2ALDH1A1HSD17B10 | |
| Bromide SCHEMBL1876279 | 0.88 | SNCA (0.59) | HTR2ASNCAHIF1ASIGMAR1 | |
| Bromide SCHEMBL11046289 | 0.87 | TSHR (0.58) | HTR2ASNCAKCNH2ALDH1A1HSD17B10 | |
| Bromide SCHEMBL2211555 | 0.86 | SNCA (0.58) | HTR2ASNCAALDH1A1CYP3A4HIF1A | |
| Bromide SCHEMBL9802322 | 0.86 | LPL (0.48) | HTR2AKCNH2LPLLIPGSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228045-B1 | AROMATIC THIOETHERS | CIBA-GEIGY AG (CH) | 1991-04-03 | — | — | EP | disclosed |
| US-4785004-A | ANTIALLERGENS, ANTIHISTAMINES | CIBA-GEIGY CORPORATION (US) | 1988-11-15 | — | — | US | disclosed |
| EP-0228045-A2 | Aromatic thioethers | CIBA-GEIGY AG (CH) | 1987-07-08 | — | — | EP | disclosed |