SCHEMBL9802185

SCHEMBL9802185

CCCCCCCCCc1cccc(Br)c1

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.61
CYP2D6 P10635 2/20 0.61
CYP2C19 P33261 2/20 0.61
LPL P06858 3/20 0.57
LIPG Q9Y5X9 3/20 0.57
TAAR1 Q96RJ0 3/20 0.55
PPARG P37231 1/20 0.49
PPARA Q07869 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1577575 1.00 CYP1A2 (0.61) CYP1A2CYP2D6CYP2C19LPLLIPG
SCHEMBL28656641 1.00 CYP1A2 (0.61) CYP1A2CYP2D6CYP2C19LPLLIPG
SCHEMBL5599017 1.00 CYP1A2 (0.61) CYP1A2CYP2D6CYP2C19LPLLIPG
SCHEMBL19304390 1.00 CYP1A2 (0.61) CYP1A2CYP2D6CYP2C19LPLLIPG
SCHEMBL2442972 1.00 CYP1A2 (0.61) CYP1A2CYP2D6CYP2C19LPLLIPG
SCHEMBL2998787 0.98 CYP1A2 (0.60) CYP1A2CYP2D6CYP2C19LPLLIPG
Nitrogen SCHEMBL23668052 0.96 CYP1A2 (0.58) CYP1A2CYP2D6CYP2C19LPLLIPG
SCHEMBL417687 0.92 TAAR1 (0.59) CYP1A2CYP2D6CYP2C19LPLLIPG
SCHEMBL19524669 0.90 TAAR1 (0.65) CYP1A2CYP2D6CYP2C19TAAR1
SCHEMBL27390155 0.90 LPL (0.51) CYP1A2CYP2D6CYP2C19LPLLIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020245297-A1 PYRROLE DERIVATIVES AS ACC INHIBITORS ALMIRALL, S.A. (ES) 2020-12-10 WO disclosed
EP-0225602-B1 ALPHA-HYDROXYTHIO ETHERS CIBA-GEIGY AG (CH) 1991-10-09 EP disclosed
EP-0228045-B1 AROMATIC THIOETHERS CIBA-GEIGY AG (CH) 1991-04-03 EP disclosed
US-4808572-A ANTIALLERGENS CIBA-GEIGY CORPORATION (US) 1989-02-28 US disclosed
US-4785004-A ANTIALLERGENS, ANTIHISTAMINES CIBA-GEIGY CORPORATION (US) 1988-11-15 US disclosed
EP-0123543-B1 LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM MERCK FROSST CANADA INC. (CA) 1988-02-03 EP disclosed
EP-0228045-A2 Aromatic thioethers CIBA-GEIGY AG (CH) 1987-07-08 EP disclosed
EP-0225602-A2 Alpha-hydroxythio ethers CIBA-GEIGY AG (CH) 1987-06-16 EP disclosed
US-4609744-A 4-oxo-benzopyran carboxylic acids MERCK FROSST CANADA INC. (CA) 1986-09-02 US disclosed
EP-0123543-A1 Leukotriene antagonists, their production and use and compositions containing them MERCK FROSST CANADA INC. (CA) 1984-10-31 EP disclosed