Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 5/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | CASP7 | P55210 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844923 | 0.81 | MEN1 (0.46) | ALDH1A1SMN1; SMN2MEN1KMT2AUSP2 | |
| SCHEMBL9803021 | 0.74 | ALDH1A1 (0.53) | PIM1PIM3ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL9802626 | 0.71 | ALDH1A1 (0.46) | PIM1PIM3ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL23537851 | 0.67 | AR (0.40) | ALDH1A1MEN1KMT2AARCASP1 | |
| SCHEMBL19212449 | 0.66 | PIM1 (1.00) | PIM1PIM3ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL9802708 | 0.66 | AR (0.40) | PIM1PIM3ALDH1A1HTTAR | |
| SCHEMBL24109425 | 0.66 | DHODH (0.40) | PIM1PIM3 | |
| SCHEMBL25249392 | 0.65 | KDM4E (0.34) | PIM1PIM3ALDH1A1KMT2AHTT | |
| SCHEMBL525412 | 0.64 | PIM1 (0.38) | PIM1PIM3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23537407 | 0.63 | ALDH1A1 (0.44) | PIM1PIM3ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068334-A | Analgesics and antipyretics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0338228-A2 | Use of quinoline-2,5-diones in a medicament having an analgesic, antipyretic and/or antiphlogistic activity | Dr. Karl Thomae GmbH (DE) | 1989-10-25 | — | — | EP | disclosed |