Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 17/20 | 0.44 |
| ▸ | RAMP1 | O60894 | 5/20 | 0.40 |
| ▸ | RAMP3 | O60896 | 1/20 | 0.36 |
| ▸ | CALCR | P30988 | 1/20 | 0.36 |
| ▸ | CALCA | P06881 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979141 | 0.92 | CALCRL (0.46) | CALCRLRAMP1RAMP3CALCRCALCA | |
| SCHEMBL979228 | 0.79 | CALCRL (0.58) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL979227 | 0.79 | CALCRL (0.58) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL12921113 | 0.74 | CALCRL (0.76) | CALCRLRAMP1RAMP3CALCRCALCA | |
| SCHEMBL13993500 | 0.73 | CALCRL (0.79) | CALCRLRAMP1RAMP3CALCRCALCA | |
| SCHEMBL13599204 | 0.73 | CALCRL (0.79) | CALCRLRAMP1RAMP3CALCRCALCA | |
| SCHEMBL13599219 | 0.73 | CALCRL (0.79) | CALCRLRAMP1RAMP3CALCRCALCA | |
| SCHEMBL977107 | 0.73 | CALCRL (0.36) | CALCRLRAMP1 | |
| SCHEMBL977138 | 0.71 | CALCRL (0.49) | CALCRLRAMP1RAMP3CALCRCALCA | |
| SCHEMBL978530 | 0.70 | CALCRL (0.36) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021516-A1 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021516-A1 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | CCKAR, CALCRL, CCKBR | CALCRL 2/4885RAMP1 169/4885RAMP3 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.