Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803053 | 0.76 | HTT (0.52) | HTTCSNK2A1PLK1PLK3HDAC1 | |
| SCHEMBL23537658 | 0.72 | BUB1 (0.43) | CSNK2A1PLK1PLK3HDAC1HDAC6 | |
| SCHEMBL29824768 | 0.72 | BUB1 (0.43) | CSNK2A1PLK1PLK3HDAC1HDAC6 | |
| SCHEMBL9803135 | 0.70 | HTT (0.40) | HTTCSNK2A1PLK1PLK3HDAC1 | |
| SCHEMBL15698058 | 0.69 | ALDH1A1 (0.43) | ALDH1A1KDM4ETSHRPTK2L3MBTL1 | |
| SCHEMBL31223986 | 0.68 | RXFP1 (0.38) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL9803110 | 0.67 | SMN1; SMN2 (0.46) | HTTCSNK2A1PLK1PLK3ALDH1A1 | |
| SCHEMBL13377320 | 0.66 | RXFP1 (0.36) | TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL6164696 | 0.65 | HTT (0.61) | HTTCSNK2A1PLK1PLK3ALDH1A1 | |
| SCHEMBL1146660 | 0.65 | HTR2A (0.51) | HDAC1HDAC6BUB1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068334-A | Analgesics and antipyretics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0338228-A2 | Use of quinoline-2,5-diones in a medicament having an analgesic, antipyretic and/or antiphlogistic activity | Dr. Karl Thomae GmbH (DE) | 1989-10-25 | — | — | EP | disclosed |