Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9802568 | 1.00 | HPGD (0.43) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL9802562 | 1.00 | HPGD (0.43) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL9802576 | 1.00 | HPGD (0.43) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL9803156 | 1.00 | HPGD (0.43) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL29136230 | 0.87 | HPGD (0.42) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL13484174 | 0.81 | HPGD (0.47) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL9766998 | 0.80 | HPGD (0.46) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL3201676 | 0.78 | DPP4 (0.50) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL3185962 | 0.78 | DPP4 (0.50) | HPGDTSHRGRM2BRD4MEN1 | |
| SCHEMBL3201687 | 0.78 | DPP4 (0.50) | HPGDTSHRGRM2BRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049577-A | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith | E. R. SQUIBB & SONS, INC. (US) | 1991-09-17 | — | — | US | disclosed |