Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | CETP | P11597 | 9/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804276 | 1.00 | MAPK14 (0.52) | MAPK14CETPLTA4HEPHX2GRIN2B | |
| SCHEMBL7932267 | 0.91 | AKR1C3 (0.42) | MAPK14CETP | |
| SCHEMBL7932271 | 0.91 | AKR1C3 (0.42) | MAPK14CETP | |
| SCHEMBL9804320 | 0.89 | KDM4E (0.48) | MAPK14CETPLTA4HGRIN2B | |
| SCHEMBL9804325 | 0.89 | KDM4E (0.48) | MAPK14CETPLTA4HGRIN2B | |
| SCHEMBL9804383 | 0.88 | CETP (0.41) | MAPK14CETPLTA4HEPHX2 | |
| SCHEMBL9804381 | 0.88 | CETP (0.41) | MAPK14CETPLTA4HEPHX2 | |
| SCHEMBL9804470 | 0.87 | MAPK14 (0.47) | MAPK14CETPLTA4HEPHX2MRGPRX4 | |
| SCHEMBL9804377 | 0.87 | PPARD (0.44) | MAPK14CETP | |
| SCHEMBL9804529 | 0.87 | PPARG (0.44) | MAPK14CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240121-B1 | DIPHENYL ETHER DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-17 | — | — | EP | claimed |
| EP-0240121-B1 | DIPHENYL ETHER DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-17 | — | — | EP | disclosed |
| EP-0390228-A2 | Chemical intermediates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-10-03 | — | — | EP | disclosed |
| US-4791139-A | Diphenyl ether derivatives and their use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-13 | — | — | US | disclosed |
| EP-0240121-A2 | Diphenyl ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-10-07 | — | — | EP | disclosed |