⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31536562 | 1.00 | — | — | |
| SCHEMBL31536659 | 1.00 | — | — | |
| SCHEMBL11621138 | 0.85 | SUCNR1 (0.38) | — | |
| SCHEMBL11567212 | 0.83 | PPP5C (0.39) | — | |
| SCHEMBL10023959 | 0.83 | SUCNR1 (0.36) | — | |
| SCHEMBL12997172 | 0.81 | SUCNR1 (0.35) | — | |
| SCHEMBL15182536 | 0.81 | PPP5C (0.38) | — | |
| SCHEMBL29281344 | 0.81 | SUCNR1 (0.40) | — | |
| SCHEMBL2684774 | 0.77 | — | — | |
| SCHEMBL21681141 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047927-A | N-acyl-N' - (pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activity | 德西费拉制药有限责任公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-105228620-B | N-acyl-N' - (pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activity | 德西费拉制药有限责任公司 | 2020-09-04 | — | — | CN | disclosed |
| EP-2968287-B1 | N-ACYL-N'-(PYRIDIN-2-YL) UREAS AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS LLC (US) | 2020-06-24 | — | — | EP | disclosed |
| CN-110563700-A | N-acyl-N' - (pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activity | 德西费拉制药有限责任公司 | 2019-12-13 | — | — | CN | disclosed |
| US-9382228-B2 | N-acyl-N′-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities | DECIPHERA PHARMACEUTICALS, LLC (US) | 2016-07-05 | — | — | US | disclosed |
| EP-2968287-A2 | N-ACYL-N'-(PYRIDIN-2-YL) UREAS AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, LLC (US) | 2016-01-20 | — | — | EP | disclosed |
| US-8940363-B2 | Preparation of hollow polymer microspheres | NAN YA PLASTICS CORPORATION (TW) | 2015-01-27 | — | — | US | disclosed |
| US-20140275080-A1 | N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities | DECIPHERA PHARMACEUTICALS, LLC (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2014145028-A2 | N-ACYL-N'-(PYRIDIN-2-YL) UREAS AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140050845-A1 | PREPARATION OF HOLLOW POLYMER MICROSPHERES | NAN YA PLASTICS CORPORATION (TW) | 2014-02-20 | — | — | US | disclosed |
| EP-0247485-B1 | PROCESS FOR THE PREPARATION OF OXETAN-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1991-04-17 | — | — | EP | disclosed |
| US-4824975-A | OXIDATION OF 3-/HYDROXYMETHYL/OXETANE | BAYER AKTIENGESELLSCHAFT (DE) | 1989-04-25 | — | — | US | disclosed |
| EP-0247485-A2 | Process for the preparation of oxetan-3-carboxylic acids | BAYER AG (DE) | 1987-12-02 | — | — | EP | disclosed |