Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10371879 | 0.86 | CYP19A1 (0.36) | CYP19A1EBPSIGMAR1CCR1POLB | |
| SCHEMBL9804855 | 0.85 | EBP (0.41) | CYP19A1EBPSIGMAR1CYP3A4 | |
| SCHEMBL9804822 | 0.84 | CYP19A1 (0.42) | CYP19A1CYP3A4CYP3A5ALDH1A1 | |
| SCHEMBL9804674 | 0.84 | CYP19A1 (0.49) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL10372451 | 0.83 | TDP1 (0.45) | CYP19A1EBPSIGMAR1CCR1L3MBTL1 | |
| SCHEMBL9804810 | 0.81 | CYP19A1 (0.39) | CYP19A1EBPSIGMAR1CCR1POLB | |
| SCHEMBL9805022 | 0.80 | CYP19A1 (0.59) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL9804705 | 0.79 | CYP19A1 (0.39) | CYP19A1EBPSIGMAR1 | |
| SCHEMBL9804866 | 0.79 | CYP19A1 (0.45) | CYP19A1EBPSIGMAR1CCR1CYP3A4 | |
| SCHEMBL9021740 | 0.78 | CCR1 (0.40) | CYP19A1EBPSIGMAR1CCR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276920-B1 | (2-CYANO-2-(PHENYL OR NAPHTHYL)-2-SUBSTITUTED-ETHYL) PYRAZINES, PYRIMIDINES AND PYRIDAZINES | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | claimed |
| EP-0276920-A1 | (2-Cyano-2-(phenyl or naphthyl)-2-substituted-ethyl) pyrazines, pyrimidines and pyridazines | ROHM AND HAAS COMPANY (US) | 1988-08-03 | — | — | EP | claimed |
| EP-0276920-B1 | (2-CYANO-2-(PHENYL OR NAPHTHYL)-2-SUBSTITUTED-ETHYL) PYRAZINES, PYRIMIDINES AND PYRIDAZINES | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| EP-0276920-A1 | (2-Cyano-2-(phenyl or naphthyl)-2-substituted-ethyl) pyrazines, pyrimidines and pyridazines | ROHM AND HAAS COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |