Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 12/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 12/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 12/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 12/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9805562 | 1.00 | CACNA1F (0.52) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9805591 | 0.88 | CACNA1F (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9805597 | 0.88 | CACNA1F (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9805535 | 0.87 | CACNA1F (0.50) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9805543 | 0.87 | CACNA1F (0.50) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7265084 | 0.86 | CACNA1F (0.66) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9475039 | 0.84 | CACNA1F (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9478573 | 0.80 | CACNA1F (0.64) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7267141 | 0.80 | CACNA1F (0.63) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL8329610 | 0.78 | CACNA1F (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234830-B1 | 2-(SUBSTITUTED IMINO)-6-ARYL-3,6-DIHYDRO-4-SUBSTITUTED-1,5(2H)-PYRIMIDINECARBOXYLIC ACIDS AND ANALOGS | E.R. Squibb & Sons, Inc. (US) | 1991-04-24 | — | — | EP | disclosed |
| EP-0234830-A1 | 2-(Substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs | E.R. Squibb & Sons, Inc. (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4689414-A | 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs | E. R. SQUIBB & SONS, INC. (US) | 1987-08-25 | — | — | US | disclosed |