Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | CASP1 | P29466 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160175 | 0.90 | KDM4E (0.90) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL7266705 | 0.88 | KDM4E (0.90) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL7272456 | 0.87 | KDM4E (0.67) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL7265381 | 0.86 | KDM4E (0.55) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL7266460 | 0.86 | KDM4E (0.55) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL7267832 | 0.85 | HSD17B10 (0.54) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL11681059 | 0.84 | KDM4E (0.62) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL7265761 | 0.84 | KDM4E (0.70) | KDM4EHSD17B10CASP1ALDH1A1CACNA1B | |
| SCHEMBL11681065 | 0.84 | KDM4E (0.70) | KDM4EHSD17B10CASP1ALDH1A1CASP7 | |
| SCHEMBL7160171 | 0.83 | KDM4E (1.00) | KDM4EHSD17B10CASP1ALDH1A1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1261348-A | Dihydropyridine derivatives | AJINOMTO CO INC (JP) | 2000-07-26 | — | — | CN | disclosed |
| US-5064839-A | Vasodilators, coronary disorders, hypotensive | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1991-11-12 | — | — | US | disclosed |
| US-4771057-A | TREATMENT OF ANGINA, ARRHYTHMIAS, CEREBRALVASCULAR DISEASE AND HYPERTENSION | UNIVERSITY OF ALBERTA (CA) | 1988-09-13 | — | — | US | disclosed |
| EP-0239186-A1 | Antihypertensive reduced pyridyl derivatives | The Governors of the University of Alberta (CA) | 1987-09-30 | — | — | EP | disclosed |