Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | CASP1 | P29466 | 3/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806876 | 0.86 | KDM4E (0.71) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL7160175 | 0.78 | KDM4E (0.90) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL7266460 | 0.77 | KDM4E (0.55) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL7272409 | 0.76 | ALDH1A1 (0.43) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL7267832 | 0.76 | HSD17B10 (0.54) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL7266705 | 0.76 | KDM4E (0.90) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL7272456 | 0.75 | KDM4E (0.67) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL11681065 | 0.75 | KDM4E (0.70) | KDM4EHSD17B10CASP1CASP7ALDH1A1 | |
| SCHEMBL7267045 | 0.74 | CACNA1B (0.39) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL11681059 | 0.72 | KDM4E (0.62) | KDM4EHSD17B10CASP1CASP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920225-A | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1990-04-24 | — | — | US | disclosed |
| EP-0273349-A2 | Resolution of 1,4-dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1988-07-06 | — | — | EP | disclosed |