SCHEMBL9808970

SCHEMBL9808970

CSCSC[C@H](NC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 10/20 0.57
PPARG P37231 9/20 0.57
PPARD Q03181 2/20 0.55
CYP1A2 P05177 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
HTT P42858 1/20 0.53
CTSS P25774 4/20 0.48
CTSK P43235 4/20 0.48
SMN1; SMN2 Q16637 1/20 0.46
CTSL P07711 1/20 0.45
CTSB P07858 1/20 0.45
ALDH1A1 P00352 3/20 0.44
MAPT P10636 3/20 0.44
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
PKM P14618 1/20 0.43
HPGD P15428 1/20 0.43
ALOX12 P18054 1/20 0.43
ACE P12821 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9808989 1.00 PPARA (0.57) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL2313666 0.89 PPARA (0.57) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL23927278 0.89 PPARA (0.64) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL1618767 0.89 PPARA (0.57) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL46641 0.89 PPARA (0.57) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL9809033 0.87 CYP1A2 (0.49) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL3068819 0.84 PPARA (0.60) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL3068817 0.84 PPARA (0.60) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL3068814 0.84 PPARA (0.60) PPARAPPARGPPARDCYP1A2CYP2C9
SCHEMBL9046147 0.83 PPARG (0.59) PPARAPPARGPPARDCYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0322633-B1 MERCAPTO-ACYLAMINO ACID ANTIHYPERTENSIVES SCHERING CORPORATION (US) 1991-05-22 EP disclosed
EP-0390839-A1 MERCAPTO-ACYLAMINO ACID ANTIHYPERTENSIVES SCHERING CORPORATION (US) 1990-10-10 EP disclosed
EP-0322633-A1 Mercapto-acylamino acid antihypertensives SCHERING CORPORATION (US) 1989-07-05 EP disclosed
WO-1989005796-A1 MERCAPTO-ACYLAMINO ACID ANTIHYPERTENSIVES SCHERING CORPORATION (US) 1989-06-29 WO disclosed