Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Moexipril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 15/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Moexipril SCHEMBL30903896 | 1.00 | ACE (0.98) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL5386742 | 1.00 | ACE (0.98) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL28096307 | 1.00 | ACE (0.98) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL14660386 | 1.00 | ACE (0.98) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL29383460 | 1.00 | ACE (0.98) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL40877 | 1.00 | ACE (0.98) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL3967866 | 1.00 | ACE (0.98) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL11268790 | 0.99 | ACE (0.97) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL6508276 | 0.99 | ACE (1.00) | ACEPDE3AABCB11LMNASMN1; SMN2 | |
| Moexipril SCHEMBL678818 | 0.99 | ACE (1.00) | ACEPDE3AABCB11LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322633-B1 | MERCAPTO-ACYLAMINO ACID ANTIHYPERTENSIVES | SCHERING CORPORATION (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0390839-A1 | MERCAPTO-ACYLAMINO ACID ANTIHYPERTENSIVES | SCHERING CORPORATION (US) | 1990-10-10 | — | — | EP | disclosed |
| EP-0322633-A1 | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-07-05 | — | — | EP | disclosed |
| WO-1989005796-A1 | MERCAPTO-ACYLAMINO ACID ANTIHYPERTENSIVES | SCHERING CORPORATION (US) | 1989-06-29 | — | — | WO | disclosed |