SCHEMBL9809143

SCHEMBL9809143

CC1(Cc2ccccc2)NCCc2ccccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.40
BACE1 P56817 1/20 0.38
SIGMAR1 Q99720 6/20 0.37
TP53 P04637 2/20 0.37
CYP1A2 P05177 2/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 2/20 0.37
TSHR P16473 2/20 0.37
CYP2C19 P33261 2/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP2C9 P11712 1/20 0.37
SLC22A1 O15245 1/20 0.36
PRCP P42785 1/20 0.36
HTR2A P28223 3/20 0.36
DRD2 P14416 1/20 0.35
NFKB1 P19838 1/20 0.35
HTR2C P28335 1/20 0.35
MAPK1 P28482 1/20 0.35
HTR2B P41595 1/20 0.35
MTOR P42345 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8820020 0.81 HTR2A (0.39) MEN1HTR2AHTR2CKMT2A
SCHEMBL5102164 0.81 MEN1 (0.40) MEN1BACE1SIGMAR1TP53CYP1A2
SCHEMBL12489590 0.80 HTR2A (0.38) MEN1HTR2AHTR2C
SCHEMBL34420059 0.80 MEN1 (0.41) MEN1BACE1SIGMAR1TP53CYP1A2
SCHEMBL7175933 0.80 MEN1 (0.41) MEN1BACE1SIGMAR1TP53CYP1A2
SCHEMBL8820220 0.79 HTR2A (0.37) MEN1SIGMAR1HTR2AHTR2C
SCHEMBL175960 0.76 MEN1 (0.39) MEN1SIGMAR1HTR2A
SCHEMBL28038157 0.76 LNPEP (0.40) MEN1CYP3A4TSHRALDH1A1KMT2A
SCHEMBL27799486 0.74 MEN1 (0.38) MEN1SIGMAR1TP53CYP1A2CYP3A4
SCHEMBL29674239 0.73 HTR2A (0.43) HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3109325-A None JP disclosed
JP-3109325-A None JP disclosed
JP-H03109325-A PHARMACEUTICAL COMPOSITION CONTAINING AS ACTIVE INGREDIENT 1-METHYL-1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE OR SALT THEREOF FUJISAWA PHARMACEUT CO LTD 1991-05-09 JP disclosed
JP-H03109325-A PHARMACEUTICAL COMPOSITION CONTAINING AS ACTIVE INGREDIENT 1-METHYL-1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE OR SALT THEREOF FUJISAWA PHARMACEUT CO LTD 1991-05-09 JP disclosed