Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GPR3 | P46089 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8096275 | 1.00 | KDM4E (0.58) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| Bicarbonate SCHEMBL9168209 | 1.00 | KDM4E (0.58) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| Acetic Acid SCHEMBL914220 | 0.91 | KDM4E (0.55) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| Carbamic Acid SCHEMBL21176817 | 0.91 | KDM4E (0.55) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| SCHEMBL11365946 | 0.91 | KDM4E (0.59) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| SCHEMBL30515127 | 0.91 | GPR3 (0.68) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| SCHEMBL29374932 | 0.91 | GPR3 (0.68) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| SCHEMBL9160474 | 0.91 | GPR3 (0.68) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| SCHEMBL36332 | 0.91 | GPR3 (0.68) | KDM4EGPR3ALDH1A1MAPTNPC1 | |
| SCHEMBL10476774 | 0.91 | GPR3 (0.68) | KDM4EGPR3ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198798-B1 | LIGHT-SENSITIVE POLYCONDENSATES, PROCESS FOR THEIR PREPARATION, MATERIALS COATED THEREWITH AND THEIR USE | CIBA-GEIGY AG (CH) | 1991-05-29 | — | — | EP | disclosed |
| EP-0198798-A2 | Light-sensitive polycondensates, process for their preparation, materials coated therewith and their use | CIBA-GEIGY AG (CH) | 1986-10-22 | — | — | EP | disclosed |