Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 5/20 | 0.60 |
| ▸ | MAOB | P27338 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4538420 | 0.96 | ALDH1A1 (0.65) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Bromide SCHEMBL28646960 | 0.93 | ALDH1A1 (0.61) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Bromide SCHEMBL11532977 | 0.93 | ALDH1A1 (0.61) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Bromide SCHEMBL11283419 | 0.93 | ALDH1A1 (0.61) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Hydrochloric Acid SCHEMBL3787902 | 0.93 | MAOB (0.65) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Bromide SCHEMBL11550987 | 0.93 | ALDH1A1 (0.61) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Bromide SCHEMBL11513180 | 0.93 | ALDH1A1 (0.61) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL9741303 | 0.93 | ALDH1A1 (0.69) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL62125 | 0.93 | ALDH1A1 (0.69) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Benzene SCHEMBL3440179 | 0.93 | ALDH1A1 (0.69) | ALDH1A1HPGDALOX15ALOX12CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0246414-B1 | METHOD OF SUPPRESSING SODIUM POISONING OF CRACKING CATALYSTS DURING FLUID CATALYTIC CRACKING | CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) | 1991-06-26 | — | — | EP | disclosed |
| US-4889617-A | PASSIVATION WITH TIN OR TIN COMPOUNDS | CHEVRON RESEARCH COMPANY (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0246414-A1 | Method of suppressing sodium poisoning of cracking catalysts during fluid catalytic cracking | CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) | 1987-11-25 | — | — | EP | disclosed |