Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9811837 | 0.81 | NPC1 (0.50) | CA12CA9ALDH1A1MEN1KMT2A | |
| SCHEMBL9811900 | 0.81 | CA12 (0.55) | POLBCA12MAPTALDH1A1MEN1 | |
| SCHEMBL9338142 | 0.81 | ALDH1A1 (0.56) | POLBCA12CA9MAPTALDH1A1 | |
| SCHEMBL233680 | 0.78 | CA9 (0.50) | CA12CA9ALDH1A1MEN1KMT2A | |
| SCHEMBL9811890 | 0.77 | HTT (0.58) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL9811846 | 0.77 | CA12 (0.58) | CA12ALDH1A1SMN1; SMN2TP53EPHX2 | |
| SCHEMBL11882145 | 0.74 | POLB (0.63) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL21056246 | 0.73 | MEN1 (0.61) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11758471 | 0.73 | MAPT (0.61) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10623171 | 0.73 | CA9 (0.58) | CA12CA9MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243173-B1 | NEW DIPHOSPHONIC ACID COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-06-26 | — | — | EP | disclosed |
| US-4963536-A | INHIBIT BONE RESORPTION | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-10-16 | — | — | US | disclosed |
| US-4857513-A | Diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISIWA PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0243173-A2 | New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-28 | — | — | EP | disclosed |
| US-4124371-A | α,α-DIPHOSPHONATO ACETANILIDES | MONSANTO COMPANY (US) | 1978-11-07 | — | — | US | disclosed |
| US-4124371-A | α,α-DIPHOSPHONATO ACETANILIDES | MONSANTO COMPANY (US) | 1978-11-07 | — | — | US | disclosed |
| US-3906062-A | Alpha,alpha-diphosphonato acetanilides | MONSANTO CO | 1975-09-16 | — | — | US | disclosed |
| US-3906062-A | Alpha,alpha-diphosphonato acetanilides | MONSANTO CO | 1975-09-16 | — | — | US | disclosed |