Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9811986 | 1.00 | ABCB1 (0.50) | ABCB1MAOBADRB2ADRB1LMNA | |
| SCHEMBL9812047 | 0.92 | ABCB1 (0.53) | ABCB1MAOBADRB2ADRB1CYP1A2 | |
| SCHEMBL9812066 | 0.92 | ABCB1 (0.53) | ABCB1MAOBADRB2ADRB1CYP1A2 | |
| SCHEMBL9811965 | 0.90 | ABCB1 (0.42) | ABCB1MAOBADRB2ADRB1LMNA | |
| SCHEMBL9811991 | 0.90 | ABCB1 (0.42) | ABCB1MAOBADRB2ADRB1LMNA | |
| SCHEMBL9811980 | 0.90 | ABCB1 (0.42) | ABCB1MAOBADRB2ADRB1LMNA | |
| SCHEMBL9811926 | 0.89 | MAOB (0.50) | ABCB1MAOB | |
| SCHEMBL9811922 | 0.89 | MAOB (0.50) | ABCB1MAOB | |
| SCHEMBL9811915 | 0.89 | MAOB (0.50) | ABCB1MAOB | |
| SCHEMBL9811971 | 0.87 | ABCB1 (0.42) | ABCB1MAOBADRB2ADRB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170121-B1 | 2-HYDROXY-3-ARYLOXYPROPYL OR 2-HYDROXY-2-BENZOFURANYL ETHYL TERTIARY AMINE HAVING AN ANTI-HYPERGLYCAEMIC AND/OR ANTI-OBESITY ACTIVITY | BEECHAM GROUP PLC (GB) | 1991-06-19 | — | — | EP | claimed |
| EP-0170121-A1 | 2-Hydroxy-3-aryloxypropyl or 2-hydroxy-2-benzofuranyl ethyl tertiary amine having an anti-hyperglycaemic and/or anti-obesity activity | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | claimed |
| EP-0170121-B1 | 2-HYDROXY-3-ARYLOXYPROPYL OR 2-HYDROXY-2-BENZOFURANYL ETHYL TERTIARY AMINE HAVING AN ANTI-HYPERGLYCAEMIC AND/OR ANTI-OBESITY ACTIVITY | BEECHAM GROUP PLC (GB) | 1991-06-19 | — | — | EP | disclosed |
| EP-0170121-A1 | 2-Hydroxy-3-aryloxypropyl or 2-hydroxy-2-benzofuranyl ethyl tertiary amine having an anti-hyperglycaemic and/or anti-obesity activity | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | disclosed |