Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9812052 | 1.00 | SLC6A4 (0.56) | SLC6A4ADRB2ADRB1ADRB3TAAR1 | |
| SCHEMBL9651945 | 0.87 | SLC6A4 (0.56) | SLC6A4ADRB2ADRB1ADRB3TAAR1 | |
| SCHEMBL14944934 | 0.87 | SLC6A4 (0.56) | SLC6A4ADRB2ADRB1ADRB3TAAR1 | |
| Hydrochloric Acid SCHEMBL9765308 | 0.85 | SLC6A4 (0.54) | SLC6A4ADRB2ADRB1ADRB3TAAR1 | |
| SCHEMBL8734031 | 0.84 | SLC6A4 (0.57) | SLC6A4ADRB2ADRB1ADRB3TAAR1 | |
| SCHEMBL8734027 | 0.84 | SLC6A4 (0.57) | SLC6A4ADRB2ADRB1ADRB3TAAR1 | |
| SCHEMBL11253726 | 0.84 | SLC6A4 (0.57) | SLC6A4ADRB2ADRB1ADRB3TAAR1 | |
| SCHEMBL10529495 | 0.83 | TDP1 (0.49) | ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL10529506 | 0.83 | TDP1 (0.49) | ADRB2ADRB1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9264979 | 0.83 | SLC6A4 (0.56) | SLC6A4ADRB2ADRB1ADRB3TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170121-B1 | 2-HYDROXY-3-ARYLOXYPROPYL OR 2-HYDROXY-2-BENZOFURANYL ETHYL TERTIARY AMINE HAVING AN ANTI-HYPERGLYCAEMIC AND/OR ANTI-OBESITY ACTIVITY | BEECHAM GROUP PLC (GB) | 1991-06-19 | — | — | EP | disclosed |
| EP-0170121-A1 | 2-Hydroxy-3-aryloxypropyl or 2-hydroxy-2-benzofuranyl ethyl tertiary amine having an anti-hyperglycaemic and/or anti-obesity activity | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | disclosed |