Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9651945 | 1.00 | SLC6A4 (0.56) | SLC6A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9765308 | 0.98 | SLC6A4 (0.54) | SLC6A4ALDH1A1TSHRALOX15SMN1; SMN2 | |
| SCHEMBL6539185 | 0.90 | ALDH1A1 (0.68) | SLC6A4ALDH1A1TSHRADRB2ADRB1 | |
| SCHEMBL9812052 | 0.87 | SLC6A4 (0.56) | SLC6A4TAAR1ADRB2ADRB1ADRB3 | |
| SCHEMBL9812059 | 0.87 | SLC6A4 (0.56) | SLC6A4TAAR1ADRB2ADRB1ADRB3 | |
| SCHEMBL22013182 | 0.86 | ALOX15 (0.55) | ALDH1A1TSHRALOX15SMN1; SMN2MAPT | |
| SCHEMBL12086478 | 0.86 | ALDH1A1 (0.58) | ALDH1A1TSHRALOX15SMN1; SMN2ADRB2 | |
| SCHEMBL14032600 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TSHRALOX15SMN1; SMN2ADRB2 | |
| SCHEMBL10702376 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TSHRALOX15SMN1; SMN2ADRB2 | |
| SCHEMBL8734031 | 0.84 | SLC6A4 (0.57) | SLC6A4ALDH1A1TAAR1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000555-B2 | Monomethylvaline compounds having phenylalanine side-chain modification at the C-terminus | SEATTLE GENETICS, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20130123465-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | SEATTLE GENETICS, INC. (US) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123465-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | MMAB, PTMS, DNPEP | SLC6A4 3408/4885ALDH1A1 3562/4885TSHR 3534/4885 |
| US-10000555-B2 | Monomethylvaline compounds having phenylalanine side-chain modification at the C-terminus | PTMS, MMAB, DNPEP | SLC6A4 3371/4885ALDH1A1 3502/4885TSHR 3599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.