Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9812354 | 1.00 | DHODH (0.69) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9812450 | 0.90 | DHODH (0.66) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9812454 | 0.90 | DHODH (0.66) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9812384 | 0.87 | DHODH (0.63) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9812387 | 0.87 | DHODH (0.63) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9812374 | 0.87 | DHODH (0.78) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9812376 | 0.87 | DHODH (0.78) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL12312432 | 0.83 | DHODH (0.82) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| Teriflunomide SCHEMBL2760666 | 0.82 | DHODH (1.00) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| Teriflunomide SCHEMBL22661 | 0.82 | DHODH (1.00) | DHODHMEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257882-B1 | N-PHENYL BUTENAMIDES WITH PHARMACEUTICAL PROPERTIES | LILLY INDUSTRIES LIMITED (GB) | 1991-07-24 | — | — | EP | disclosed |
| US-4892963-A | IMMUNE DISEASES | LILLY INDUSTRIES LIMITED (GB) | 1990-01-09 | — | — | US | disclosed |
| EP-0257882-A1 | N-Phenyl butenamides with pharmaceutical properties | LILLY INDUSTRIES LIMITED (GB) | 1988-03-02 | — | — | EP | disclosed |