Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Teriflunomide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH known ✓ | Q02127 | 9/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Teriflunomide SCHEMBL993119 | 1.00 | DHODH (1.00) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL2760666 | 1.00 | DHODH (1.00) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL20214092 | 1.00 | DHODH (1.00) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL8466730 | 0.99 | DHODH (0.97) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL991312 | 0.99 | DHODH (0.97) | DHODHEPHX2TRPV1NPC1RAB9A | |
| Teriflunomide SCHEMBL992140 | 0.99 | DHODH (0.97) | DHODHEPHX2TRPV1NPC1RAB9A | |
| SCHEMBL9079302 | 0.92 | DHODH (0.85) | DHODHEPHX2TRPV1 | |
| SCHEMBL8808801 | 0.92 | DHODH (0.85) | DHODHEPHX2TRPV1 | |
| SCHEMBL12312432 | 0.90 | DHODH (0.82) | DHODHALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL8404982 | 0.88 | DHODH (0.79) | DHODHEPHX2TRPV1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9053 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260138987-A1 | MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS | CONTINEUM THERAPEUTICS INC (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026107075-A1 | METHODS OF TREATING MULTIPLE SCLEROSIS WITH CD19-CD20 DUAL CAR-T CELLS | GENENTECH, INC. (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| US-12617762-B2 | Carboxy derivatives with antiinflamatory properties | SITRYX THERAPEUTICS LIMITED (GB) | 2026-05-05 | — | — | US | claimed |
| US-20260108501-A1 | PHARMACEUTICAL COMBINATION COMPRISING PONESIMOD | VANDA PHARMACEUTICALS INC (US) | 2026-04-23 | — | — | US | claimed |
| US-20260097039-A1 | METHODS FOR TREATING A FATTY LIVER DISEASE | MADRIGAL PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | claimed |
| US-20260085061-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2026-03-26 | — | — | US | claimed |
| EP-4087577-B1 | TREATMENT OF MEMBRANOUS NEPHROPATHY, IGG4-RELATED DISEASE, AND ANTIPHOSPHOLIPID SYNDROME USING BTK INHIBITOR 2-[(3R)-3-[4-AMINO-3-(2-FLUORO-4-PHENOXY-PHENYL)PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]PIPERIDINE-1-CARBONYL]-4-METHYL-4-[4-(OXETAN-3-YL)PIPERAZIN-1-YL]PENT-2-ENENITRILE | PRINCIPIA BIOPHARMA INC (US) | 2026-03-25 | — | — | EP | claimed |
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | claimed |
| US-5519042-A | Method of treating hyperproliferative vascular disease | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-21 | — | — | US | claimed |
| US-5504084-A | N-(4-TRIFLUOROMETHYLPHENYL) SUBSTITUTION ON 5-METHYL-ISOXAZOLE-4-CARBOXAMIDE OR 2-CYANO-3-HYDROXYCROTONAMIDE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | claimed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | claimed |
| US-5459163-A | Treatment of lupus, graft-versus-host diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-17 | — | — | US | claimed |
| EP-0665013-A1 | Method of treating hyperproliferative vascular disease | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-02 | — | — | EP | claimed |
| WO-1994024095-A1 | IMMUNOSUPPRESSIVE AGENTS | ABBOTT LABORATORIES (US) | 1994-10-27 | — | — | WO | claimed |
| EP-0617959-A1 | Pharmaceutical for the treatment of skin disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-05 | — | — | EP | claimed |
| EP-0527736-A1 | ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS. | HOECHST AG (DE) | 1993-02-24 | — | — | EP | claimed |
| WO-1991017748-A1 | ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-11-28 | — | — | WO | claimed |